Search on: RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS 
Descriptors Found: 1
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Descriptor English:   Rho Guanine Nucleotide Exchange Factors 
Descriptor Spanish:   Factores de Intercambio de Guanina Nucleótido Rho 
Descriptor Portuguese:   Fatores de Troca de Nucleotídeo Guanina Rho 
Synonyms English:   ARHGEF1
Cool-1 Protein
PAK-Interacting Exchange Factor beta
Rho Guanine Nucleotide Exchange Factor (GEF) 1
Rho Guanine Nucleotide Exchange Factor 6
Rho Guanine Nucleotide Exchange Factor 7
Rho Guanine Nucleotide Exchange Factor p115
RhoGEF
beta PIX Protein
betaPIX Protein
p115 RhoGEF
p115RhoGEF
Cool 1 Protein
PAK Interacting Exchange Factor beta
PIX Protein, beta
Protein, Cool-1
Protein, beta PIX
Protein, betaPIX
RhoGEF, p115  
Tree Number:   D12.644.360.325.300.099
D12.776.476.325.300.099
Definition English:   Signaling proteins which function as master molecular switches by activating Rho GTPases through conversion of guanine nucleotides. Rho GTPases in turn control many aspects of cell behavior through the regulation of multiple downstream signal transduction pathways. 
History Note English:   2014 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   55310 
Unique Identifier:   D064067 

Occurrence in VHL:
 

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